Reach Us +44-20-3608-4181


Simultaneous Electrochemical Determination of Articaine HCl and Epinephrine

A simple, precise, accurate and inexpensive voltammetric method was developed for the simultaneous determination of articaine HCl and epinephrine in bulk, pharmaceutical formulations and human urine at carbon paste electrode in Britton-Robinson buffer of pH 7 and 40 μL of 10−2 mol L−1 sodium dodecyl sulphate. Several factors were studied such as buffer type, pH, surfactant, scan rate, and accumulation time to obtain the optimum conditions for analysis. The method showed linearity in concentration range of 1.0 × 10−6-2.6 × 10-5 mol L−1. The limits of detection and quantitation were found 2.88 × 10−7 mol L−1 and 8.72 × 10−7 mol L−1 for articaine HCl and 5.10 × 10−8 mol L−1 and 1.56 × 10-7 for epinephrine, respectively. The proposed voltammetric method was successfully applied for simultaneous determination of articaine HCl and epinephrine in bulk, injections and urine. The results obtained from the proposed method were statistically compared with those of a reported method and showed no significant difference. Thus, it can be used as quality control in laboratories.


Ali Attia K, Noha Rashed S, Manal Fouad M and Reem Wasfy A

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Recommended Conferences
Flyer image
Abstracted/Indexed in
  • Index Copernicus
  • Google Scholar
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Secret Search Engine Labs